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| MITE Accession | Status | Enzyme Name | Tailoring Reaction | Enzyme Description | Organism | Family | Reaction Description |
|---|---|---|---|---|---|---|---|
| MITE0000001 | AviG2 | Methylation | O-methyltransferase | Streptomyces viridochromogenes Tue57 | Streptomycetaceae | AviG2 is responsible for methylation of the hydroxyl group at position 6... | |
| MITE0000002 | AviG4 | Methylation | O-methyltransferase | Streptomyces viridochromogenes Tue57 | Streptomycetaceae | O-methyltransferase and is responsible for methylation of the phenolic h... | |
| MITE0000003 | AviG6 | Methylation | O-methyltransferase | Streptomyces viridochromogenes Tue57 | Streptomycetaceae | AviG6 for methylation of the hydroxyl group at position 2 of the D-manno... | |
| MITE0000004 | AviG5 | Methylation | O-methyltransferase | Streptomyces viridochromogenes Tue57 | Streptomycetaceae | methylation of the hydroxyl group at position 4 of the D-fucose moiety | |
| MITE0000005 | CalO3 | Halogenation | Flavin-dependent halogenase | Micromonospora echinospora | Micromonosporaceae | Iodination of orsellenic acid derivate, assumed to be bound to coenzyme ... | |
| MITE0000006 | CalO6 | Methylation | O-methyltransferase | Micromonospora echinospora | Micromonosporaceae | O-methylation of orsellenic acid, assumed to be bound to coenzyme A cofactor | |
| MITE0000007 | CalO1 | Methylation | O-methyltransferase | Micromonospora echinospora | Micromonosporaceae | O-methylation of iodinated orsellenic acid derivate, assumed to be bound... | |
| MITE0000008 | CalO2 | Hydroxylation | Cytochrome P450me | Micromonospora echinospora | Micromonosporaceae | Hydroxylation of iodinated orsellenic acid derivate, assumed to be bound... | |
| MITE0000009 | MeiD | Methylation | O-methyltransferase | Streptomyces nanchangensis | Streptomycetaceae | No description | |
| MITE0000010 | MeiE | Heterocyclization|Hydroxylation | Cytochrome P450 | Streptomyces nanchangensis | Streptomycetaceae | No description | |
| MITE0000011 | MpaG | Methylation | O-methyltransferase | Penicillium brevicompactum | Eurotiomycetes | Catalyzes the O-methylation of demethylmycophenolic acid into mycophenolic acid | |
| MITE0000012 | GrhO5 | Monooxygenation | Flavoprotein monooxygenase | Streptomyces sp. JP95 | Streptomycetaceae | No description | |
| MITE0000013 | GrhO6 | Monooxygenation | Flavoprotein monooxygenase | Streptomyces sp. JP95 | Streptomycetaceae | No description | |
| MITE0000014 | MtmMI | Methylation | O-methyltransferase | Streptomyces argillaceus | Streptomycetaceae | 4-DPMC is the first stable intermediate of the mithramycin biosynthesis.... | |
| MITE0000015 | MtmMII | Methylation | C-methyltransferase | Streptomyces argillaceus | Streptomycetaceae | No description | |
| MITE0000016 | MtmOIV | Decarboxylation|Oxidation | Oxygenase | Streptomyces argillaceus | Streptomycetaceae | No description | |
| MITE0000017 | MtmW | Reduction | ketoreductase | Streptomyces argillaceus | Streptomycetaceae | No description | |
| MITE0000018 | MtmGIV | Glycosylation | glycosyltransferase | Streptomyces argillaceus | Streptomycetaceae | No description | |
| MITE0000019 | MtmGIII | Glycosylation | glycosyltransferase | Streptomyces argillaceus | Streptomycetaceae | No description | |
| MITE0000020 | MtmGII | Glycosylation | glycosyltransferase | Streptomyces argillaceus | Streptomycetaceae | No description | |
| MITE0000021 | SsfM2 | Methylation | O-methyltransferase | Streptomyces sp. SF2575 | Streptomycetaceae | No description | |
| MITE0000022 | SsfM4 | Methylation | C-methyltransferase | Streptomyces sp. SF2575 | Streptomycetaceae | SsfM4 catalyzes C6-methylation | |
| MITE0000023 | SsfM1 | Methylation | O-methyltransferase | Streptomyces sp. SF2575 | Streptomycetaceae | No description | |
| MITE0000024 | XanH | Halogenation | FAD Halogenase | Streptomyces flavogriseus | Streptomycetaceae | No description | |
| MITE0000025 | OxyB | Cyclization | Cytochrome P450 monooxygenase | Amycolatopsis orientalis | Pseudonocardiaceae | Introduces the first crosslink (biaryl ether) between hpg4 and bht6 of t... | |
| MITE0000026 | OxyA | Cyclization | Cytochrome P450 monooxygenase. | Amycolatopsis orientalis | Pseudonocardiaceae | Introduces the second crosslink (biaryl ether). | |
| MITE0000027 | OxyC | Cyclization | Cytochrome P450 monooxygenase | Amycolatopsis orientalis | Pseudonocardiaceae | Installs a biaryl ether bond on the balhiycin precursor. The reaction mi... | |
| MITE0000028 | BhaA | Halogenation | Halogenase | Amycolatopsis balhimycina | Pseudonocardiaceae | The halogenase chlorinates the second bht residue of the balhimycin prec... | |
| MITE0000029 | KtzQ | Halogenation | Flavin-dependent halogenase | Kutzneria sp. (strain 744) | Pseudonocardiaceae | KtzQ is a regiospecific halogenase that catalyzes the chlorination of L-... | |
| MITE0000030 | KtzR | Halogenation | Flavin-dependent halogenase | Kutzneria sp. (strain 744) | Pseudonocardiaceae | KtzR is a regiospecific halogenase that catalyzes chlorination at the 6-... | |
| MITE0000031 | SacF | Methylation | SAM-dependent methyltransferase | Pseudomonas fluorescens | Pseudomonadaceae | No description | |
| MITE0000032 | SfmM2 | Methylation | SAM-dependent C-methyltransferase | Streptomyces lavendulae | Streptomycetaceae | Mediates the methylation of tyrosine into 3-methyl-L-tyrosine (3-Me-Tyr)... | |
| MITE0000033 | GtfB | Glycosylation | Glycosyltransferase | Actinoplanes teichomyceticus | Micromonosporaceae | Adds N-acetylglucosamine or N-acylglucosamine to Hpg4 of the teicoplanin... | |
| MITE0000034 | GtfA | Glycosylation | Glycosyltransferase | Actinoplanes teichomyceticus | Micromonosporaceae | Glycosyltransferase adds N-acetylglucosamine to Bht6 of the teicoplanin... | |
| MITE0000035 | Tcp24 a.k.a Orf2* a.k.a. tAtf | Acylation|Hydrolysis | Acyltransferase | Actinoplanes teichomyceticus | Micromonosporaceae | Deacetylates N-acetylglucosaminyl residue on Hpg4 of the teicoplanin precursor. | |
| MITE0000036 | tAtf | Acylation | Acyltransferase | Actinoplanes teichomyceticus | Micromonosporaceae | Deacetylates N-acetylglucosaminyl residue on Hpg4 of the teicoplanin precursor. | |
| MITE0000037 | GtfE | Glycosylation | Glycosyltransferase | Amycolatopsis orientalis | Pseudonocardiaceae | Transfers glucose onto hpg4 in the vancomycin and teicoplanin aglycone. | |
| MITE0000038 | OxyA | Cyclization|Oxidation | Cytochrome P450 Monooxygenase | Amycolatopsis orientalis | Pseudonocardiaceae | Introduces the second biaryl-ether crosslink between bht2 and hpg4 in th... | |
| MITE0000039 | Vmt | Methylation | Methyltransferase | Amycolatopsis orientalis | Pseudonocardiaceae | Methylates the N-terminus of the vancomycin backbone. Substrate specific... | |
| MITE0000040 | VhaA | Halogenation | Flavin-dependent halogenase | Amycolatopsis orientalis | Pseudonocardiaceae | Chlorinates bht 2 and bht 6 of vancomycin. The bond to the PCP domain of... | |
| MITE0000041 | OxyB | Cyclization|Oxidation | Cytochrome P450 Monooxygenase | Amycolatopsis orientalis | Pseudonocardiaceae | Introduces the first biaryl-ether crosslink between hpg4 and bht6 in the... | |
| MITE0000042 | GtfD | Glycosylation | Glycosyltransferase | Amycolatopsis orientalis | Pseudonocardiaceae | Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone. | |
| MITE0000043 | SgvP | Heterocyclization | cytochrome P450 | Streptomyces griseoviridis | Streptomycetaceae | No description | |
| MITE0000044 | BotCYP | Decarboxylation|Oxidation | Cytochrome P450 | Streptomyces sp. BC16019 | Streptomycetaceae | P450-catalyzed oxidative decarboxylation of terminal thiazoline of bottr... | |
| MITE0000045 | BotOMT | Methylation | Carboxyl methyltransferase | Streptomyces sp. BC16019 | Streptomycetaceae | O-methylating SAM-dependent carboxyl methyltransferase from Streptomyces... | |
| MITE0000046 | BotRMT2 | Methylation | radical SAM methyltransferase | Streptomyces sp. BC16019 | Streptomycetaceae | Bottromycin-precursor acting rSAM methyltransferase from Streptomyces sp... | |
| MITE0000047 | BotRMT3 | Methylation | radical SAM methyltransferase | Streptomyces sp. BC16019 | Streptomycetaceae | Bottromycin-precursor acting rSAM methyltransferase from Streptomyces sp... | |
| MITE0000048 | BotP | Hydrolysis | Peptidase | Streptomyces sp. BC16019 | Streptomycetaceae | Cleavage of N-terminal Met from a NH2-Met-Gly-Pro-Xn chain, exposing a N... | |
| MITE0000049 | BotRMT1 | Methylation | rSAM methyltransferase | Streptomyces sp. BC16019 | Streptomycetaceae | Catalysis of radical C-methylation of Phe6 of bottromycin-precursor afte... | |
| MITE0000050 | BotAH | Hydrolysis | Aminohydrolase | Streptomyces sp. BC16019 | Streptomycetaceae | Cleaves modified bottromycin precursor peptide between thiazole8 and Met9. | |
| MITE0000051 | BotH | Epimerization | Epimerase | Streptomyces sp. BC16019 | Streptomycetaceae | epimerization of L-Asp7 to D-Asp7 of modified bottromycin precursor peptide | |
| MITE0000052 | BotC | Heterocyclization | Thiazole heterocyclisation-catalyzing YacO protein | Streptomyces sp. BC16019 | Streptomycetaceae | thiazole heterocyclisation of Cys8 of bottromycin-precursor | |
| MITE0000053 | BotCD | Cyclization | Macroamidine linkage-catalyzing YacO protein from Streptomyces sp. BC16019 | Streptomyces sp. BC16019 | Streptomycetaceae | macroamidine macrocyclization of Gly1 and Val4 of bottromycin-precursor | |
| MITE0000054 | MibH | Halogenation | Flavin-dependent halogenase | Microbispora corallina | Streptosporangiaceae | Flavin-dependent tryptophan-5-halogenase catalyzed halogenation reaction... | |
| MITE0000055 | McjC | Macrolactam formation | Lassopeptide ATP-dependent lactam synthetase (C-protein, asparagine synt... | Escherichia coli | Enterobacteriaceae | Lassopeptide macrolactam formation after N-terminal cleavage: NH2-G-G-X-... | |
| MITE0000056 | McjB | Hydrolysis | ATP-dependent protease (cysteine protease-like) | Escherichia coli | Enterobacteriaceae | ATP-dependent N-terminal cleavage of leader peptide, resulting in immatu... | |
| MITE0000057 | PntE | Oxidation | Baeyer-Villiger monooxygenase | Streptomyces arenae | Streptomycetaceae | Catalyzes the flavin-dependent Baeyer-Villiger oxidation in the biosynth... | |
| MITE0000058 | PntD | Dehydration|Oxidation | Non-Heme Iron-Dependent Dehydrogenase/Oxygenase | Streptomyces arenae | Streptomycetaceae | No description | |
| MITE0000059 | PntM | Other | Cytochrome P450 | Streptomyces arenae | Streptomycetaceae | Catalyzes oxidative rearrangement of final step in pentalenolactone pathway | |
| MITE0000060 | PntI | Oxidation | Cytochrome P450 | Streptomyces arenae | Streptomycetaceae | Carboxylation of intermediate in pentalenolactone biosynthetic pathway | |
| MITE0000061 | CotB3 | Hydroxylation | Cytochrome P450 | Streptomyces melanosporofaciens | Streptomycetaceae | No description | |
| MITE0000062 | CotB4 | Hydroxylation | Cytochrome P450 | Streptomyces melanosporofaciens | Streptomycetaceae | No description | |
| MITE0000063 | PtlD | Dehydration|Oxidation | Non-Heme Iron-Dependent Dehydrogenase/Oxygenase | Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) | Streptomycetaceae | No description | |
| MITE0000064 | PtlI | Oxidation | Cytochrome P450 | Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) | Streptomycetaceae | Catalyzes oxidation of pentalen-13-al in the neopentalenolactone pathway | |
| MITE0000065 | PtlE | Oxidation | Baeyer-Villiger monooxygenase | Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) | Streptomycetaceae | Catalyzes the flavin-dependent Baeyer-Villiger oxidation in the biosynth... | |
| MITE0000066 | RebP | Oxidation | Cytochrome P-450 | Lentzea aerocolonigenes | Pseudonocardiaceae | No description | |
| MITE0000067 | RebD | Oxidation | Dichlorochromopyrrolate synthase | Lentzea aerocolonigenes | Pseudonocardiaceae | No description | |
| MITE0000068 | RebO | Oxidation | Flavin-dependent L-tryptophan oxidase | Lentzea aerocolonigenes | Pseudonocardiaceae | No description | |
| MITE0000069 | RebH | Halogenation | tryptophane halogenase | Lentzea aerocolonigenes | Pseudonocardiaceae | No description | |
| MITE0000070 | RebC | Oxidation | Putative FAD-monooxygenase | Lentzea aerocolonigenes | Pseudonocardiaceae | FAD-dependent enzyme RebC catalyse the oxidation of two carboxylic acids... | |
| MITE0000071 | Bmp2 | Halogenation | Flavin-dependent halogenase | Pseudoalteromonas phenolica O-BC30 | Pseudoalteromonadaceae | No description | |
| MITE0000072 | TdaE | Dioxygenation | Flavoprotein dioxygenase | Not found | Not found | TdaE relies on its substrate as electron donor (rather than NAD(P)H) for... | |
| MITE0000073 | ClmAH | Hydrolysis | Amidohydrolase | Streptomyces sp. CS40 | Streptomycetaceae | removal of the leucine residue | |
| MITE0000074 | ClmM1 | Methylation | S-methyltransferase | Streptomyces sp. CS40 | Streptomycetaceae | No description | |
| MITE0000075 | ClmM2 | Methylation | O-methyltransferase | Streptomyces sp. CS40 | Streptomycetaceae | O-methylation of collismycin D | |
| MITE0000076 | JamD | Halogenation | Flavin-dependent halogenase | Lyngbya majuscula | Oscillatoriales | Flavin-dependent bromination of terminal alkyne | |
| MITE0000077 | MdpB1 | Methylation | C-methyltransferase | Actinomadura madurae | Thermomonosporaceae | C-methylation of methylsalicylic acid bound to coenzyme A. Auxiliary enz... | |
| MITE0000078 | MdpB2 | Other | CoA ligase | Actinomadura madurae | Thermomonosporaceae | No description | |
| MITE0000079 | PokM3 | Other | CoA ligase | Streptomyces diastatochromogenes | Streptomycetaceae | No description | |
| MITE0000080 | PokMT1 | Methylation | C-methyltransferase | Streptomyces diastatochromogenes | Streptomycetaceae | C-methylation of methylsalicylic acid bound to coenzyme A. Auxiliary enz... | |
| MITE0000081 | AgqB | Hydroxylation | alkylresorcinol monooxygenase | Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431) | Micromonosporaceae | No description | |
| MITE0000082 | AgqC | Methylation | alkylhydroxyhydroquinone methyltransferase | Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431) | Micromonosporaceae | No description | |
| MITE0000083 | AgqD | Prenylation | UbiA-like prenyltransferase | Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431) | Micromonosporaceae | No description | |
| MITE0000084 | NapB2 | Oxidation | Monooxygenase | Streptomyces aculeolatus | Streptomycetaceae | Oxidation of 1,3,6,8-tetrahydroxynaphthalene (THN) to flaviolin. | |
| MITE0000085 | NapB5 | Methylation | putative methyltransferase | Streptomyces aculeolatus | Streptomycetaceae | No description | |
| MITE0000086 | NapH1 | Halogenation|Heterocyclization | Vanadium-Dependent Chloroperoxidase | Streptomyces aculeolatus | Streptomycetaceae | No description | |
| MITE0000087 | RslO4 | Monooxygenation | Monooxygenase | Streptomyces bottropensis | Streptomycetaceae | RslO4 catalyzes the monooxygenation of an intermediate in the rishirilid... | |
| MITE0000088 | TlmF | Oxidation | cytochrome P450 | Salinispora pacifica DSM 45543 = CNS-863 | Micromonosporaceae | No description | |
| MITE0000089 | CPT2 | Prenylation | Nerylneryl diphosphate synthase | Solanum lycopersicum | Spermatophyta | No description | |
| MITE0000090 | TPS21 | Cyclization | Terpene cyclase | Solanum lycopersicum | Spermatophyta | Cyclization of nerylneryl diphosphate to form lycosantalene | |
| MITE0000091 | CYP71BN1 | Oxidation | Cytochrome P450 monooxygenase | Solanum lycopersicum | Spermatophyta | CYP71BN1 catalyzes the two-step oxidation of lycosantalene to lycosantalonol | |
| MITE0000092 | BorH | Halogenation | Flavin-dependent halogenase | Not found | Not found | Tryptophan-6 halogenation | |
| MITE0000093 | PhmJ | Halogenation | FAD-dependent halogenase | Leptolyngbya sp. ISBN3-Nov-94-8 | Leptolyngbyaceae | PhmJ forms the vinyl bromination in phormidolide A | |
| MITE0000094 | TnmK2 | Dioxygenation | Iterative cofactorless dioxygenase | Streptomyces sp. (strain CB03234) | Streptomycetaceae | No description | |
| MITE0000095 | TnmK1 | Cyclization | Hydrolase. | Streptomyces sp. (strain CB03234) | Streptomycetaceae | Catalyzes D-ring-forming Michael addition | |
| MITE0000096 | TnmJ | Dioxygenation | Cofactorless oxygenase | Streptomyces sp. (strain CB03234) | Streptomycetaceae | No description | |
| MITE0000097 | PumI | Oxidation | Oxidoreductase | Streptomyces sp | Streptomycetaceae | No description | |
| MITE0000098 | PumK | Other | Carboxylate-Amine Ligase | Streptomyces sp | Streptomycetaceae | No description | |
| MITE0000099 | PumJ | Other | Pseudouridine synthase | Streptomyces sp | Streptomycetaceae | No description | |
| MITE0000100 | PumG | Amination | Aminotransferase | Streptomyces sp | Streptomycetaceae | No description | |
| MITE0000101 | Cxm5 | Heterocyclization | Cytochrome P450 | Actinoplanes tsinanensis | Micromonosporaceae | No description | |
| MITE0000102 | TrlE | Other | Flavoprotein monooxygenase | Streptomyces cyaneofuscatus | Streptomycetaceae | Combines hydroxylation, decarboxylation and oxidation to generate tropol... | |
| MITE0000103 | TrlF | Other | decarboxylase, hydrolase | Streptomyces cyaneofuscatus | Streptomycetaceae | Cleaves off CoA from 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA | |
| MITE0000104 | TrlC | Hydroxylation | Oxygenase component of flavoprotein monooxygenase TrlCD | Streptomyces cyaneofuscatus | Streptomycetaceae | Catalyzes hydroxylation from 7-hydroxytropolone to 3,7-dihydroxytropolone | |
| MITE0000105 | GnmP | Methylation | Persulfide methyltransferase | Streptomyces sp. CB01883 | Streptomycetaceae | No description | |
| MITE0000106 | MstE | Cyclization | terpene cyclase | Scytonema sp. PCC 10023 | Scytonemataceae | No description | |
| MITE0000107 | Mca | Hydrolysis | amidase | Streptomyces cyslabdanicus | Streptomycetaceae | No description | |
| MITE0000108 | CldC | Oxidation | Cytochrome P450 | Streptomyces cyslabdanicus | Streptomycetaceae | No description | |
| MITE0000109 | CmxA | Cyclization|Deamination | L-lysine cyclodeaminase | Myxococcus sp | Cystobacterineae | cyclization and deamination of lysine to pipecolic acid | |
| MITE0000110 | NgnN4 | Other | Proline adenyltransferase | Nocardia argentinensis | Nocardiaceae | NgnN4 is responsible for attaching a pyrrole-moiety. | |
| MITE0000111 | NgnO3 | Other|Oxidation | Dioxygenase | Nocardia argentinensis | Nocardiaceae | NgnO3 catalyzes the formation of the ether bridge moiety at position C8/... | |
| MITE0000112 | Ngnp1 | Hydroxylation|Oxidation | Cytochrome P450 | Nocardia argentinensis | Nocardiaceae | Hydroxylation at c-2 | |
| MITE0000113 | NgnD | Cyclization | Nuclear transport factor 2 family protein | Nocardia argentinensis | Nocardiaceae | [6+4] cycloaddition; NgnD acts likely similar to a bispericyclase | |
| MITE0000114 | NgnM | Methylation | Methyltransferase | Nocardia argentinensis | Nocardiaceae | NgnM methylates the hydroxyl group at the 2-position of the macrolactone... | |
| MITE0000115 | NgnP2 | Hydroxylation|Monooxygenation|Oxidation | Cytochrome P450 | Nocardia argentinensis | Nocardiaceae | Hydroxylation at C-18 | |
| MITE0000116 | StoC | Dehydration | NADH:flavin oxidoreductase | Not found | Not found | Dehydration; elimination of primary alcohol under formation exo-methylene group | |
| MITE0000117 | StoR | Reduction | NAD(P)H-dependent oxidoreductase | Pseudomonas fluorescens | Pseudomonadaceae | NADPH dependent reduction of exo-methylene in styrolide B to methyl grou... | |
| MITE0000118 | AcaR | Reduction | NADPH-dependent oxidoreductase | Pseudomonas jessenii | Pseudomonadaceae | reduction of exocxclic double bond in dehydroacaterin to acaterin | |
| MITE0000119 | ScyL2 | Hydroxylation | AsaB-like alphaKGDD | Scytalidium album | Leotiomycetes | No description | |
| MITE0000120 | ZopL9 a.k.a. ZopK | Hydroxylation|Ring contraction | AsaB-like alphaKGDD | Diffractella curvata | Sordariomycetes | Catalyzes a ring contraction of the nine-membered central ring to yield ... | |
| MITE0000121 | AbmB | Hydroxylation | L-Ornithine N(5)-oxygenase | Streptomyces sp. ATCC 700974 | Streptomycetaceae | N-hydroxylation of delta-amine of ornithin | |
| MITE0000122 | AbmA | Acetylation | Acetyltransferase | Streptomyces sp. ATCC 700974 | Streptomycetaceae | No description | |
| MITE0000123 | JuiM | Acetylation | Acetyltransferase | Streptomyces sampsonii | Streptomycetaceae | No description | |
| MITE0000124 | JuiL | Reduction | F420-dependent oxidoreductase | Streptomyces sampsonii | Streptomycetaceae | No description | |
| MITE0000125 | JuiI | Biaryl bond formation | Cytochrome P450 | Streptomyces sampsonii | Streptomycetaceae | Biaryl coupling of two julichrome Q6 units | |
| MITE0000126 | AetF | Halogenation | Flavin-dependent halogenase | Aetokthonos hydrillicola Thurmond2011 | Hapalosiphonaceae | Bromination of L-tryptophan, leading to 5-bromotryptophan | |
| MITE0000127 | AetA | Halogenation | Flavin-dependent halogenase | Aetokthonos hydrillicola Thurmond2011 | Hapalosiphonaceae | Bromination of 5-bromoindole, leading to 3,5-tribromoindole | |
| MITE0000128 | OrfA | Halogenation | Halogenase | Streptomyces tumemacerans | Streptomycetaceae | FADH2-dependent halogenase in the biosynthesis of chloroalbofungin | |
| MITE0000129 | ThnJ | Deamination | Aminotransferase | Streptomyces sp. FXJ1.172 | Streptomycetaceae | No description | |
| MITE0000130 | ThnH | Halogenation | tryptophan 6-halogenase | Streptomyces sp. FXJ1.172 | Streptomycetaceae | chlorinates tryptophan to form 6-Cl-tryptophan (6-Cl-Trp) | |
| MITE0000131 | ThnA | Amination | amidotransferase | Streptomyces sp. FXJ1.172 | Streptomycetaceae | No description | |
| MITE0000132 | THAA2 | Acetylation | Acetyltransferase | Arabidopsis lyrata subsp. lyrata | Spermatophyta | O-acetylation as final step of the thalianin pathway in Arabidopsis thal... | |
| MITE0000133 | THAH | Hydroxylation | Cytochrome P450 | Arabidopsis lyrata subsp. lyrata | Spermatophyta | Hydroxylates the intermediate in the thalianin pathway in Arabidopsis th... | |
| MITE0000134 | THAS | Cyclization | Oxidosqualene cyclase | Not found | Not found | Cyclases the intermediate in the thalianin pathway in Arabidopsis thalia... | |
| MITE0000135 | THAO | Hydroxylation | Cytochrome P450 | Arabidopsis lyrata subsp. lyrata | Spermatophyta | Hydroxylates the intermediate in the thalianin pathway in Arabidopsis th... | |
| MITE0000136 | THAA1 | Acetylation | Acyltransferase subfamily IIIa, Arabidopsis lyrata ssp lyrata | Not found | Not found | Acetylates the intermediate in the thalianin pathway in Arabidopsis thal... | |
| MITE0000137 | AnkG | Other | ATP-grasp protein | Aspergillus thermomutatus | Eurotiomycetes | No description | |
| MITE0000138 | AnkE | Other | NRPS independent siderophore synthetase | Aspergillus thermomutatus | Eurotiomycetes | No description | |
| MITE0000139 | AnkD | Other | pyridoxal-phosphate dependent enzyme | Aspergillus thermomutatus | Eurotiomycetes | No description | |
| MITE0000140 | AnkA | Other | cRY tRNA-dependent cyclodipeptide synthase | Aspergillus thermomutatus | Eurotiomycetes | No description | |
| MITE0000141 | AnkF | Methylation | o-methyltransferase | Aspergillus thermomutatus | Eurotiomycetes | No description | |
| MITE0000142 | AnkC | Monooxygenation | FAD-dependent monooxygenase | Aspergillus thermomutatus | Eurotiomycetes | No description | |
| MITE0000143 | AvaC | Hydrolysis | kynurenine formamidase | Aspergillus versicolor | Eurotiomycetes | No description | |
| MITE0000144 | AvaB | Monooxygenation | FAD-dependent monooxygenase | Aspergillus versicolor | Eurotiomycetes | No description | |
| MITE0000145 | AvaD | Acetylation | GNAT family N-acetyltransferase | Aspergillus versicolor | Eurotiomycetes | No description | |
| MITE0000146 | AvaA | Other | cRW tRNA-dependent cyclodipeptide synthase | Aspergillus versicolor | Eurotiomycetes | No description | |
| MITE0000147 | PeuJ | Hydroxylation | FMN-dependent monooxygenase | Streptomyces peucetius subsp. caesius ATCC 27952 | Streptomycetaceae | No description | |
| MITE0000148 | PtlE | Oxidation | Baeyer-Villiger monooxygenase | Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680) | Streptomycetaceae | No description | |
| MITE0000149 | MciB | Biaryl bond formation | P450 installing crosslink | Micromonospora citrea | Micromonosporaceae | No description | |
| MITE0000150 | CYP158C1 | Biaryl bond formation | Cytochrome P450 | Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057) | Streptomycetaceae | No description | |
| MITE0000151 | PspC | Oxidation | Cytochrome P450 monooxygenase | Penicillium soppii | Eurotiomycetes | catalyzes three-step oxidations at the C-4 methyl group to carboxylic ac... | |
| MITE0000152 | ScnB | Biaryl bond formation | Cytochrome P450 | Streptomyces sp. CNQ-509 | Streptomycetaceae | Installs biaryl crosslink between trp-trp | |
| MITE0000153 | SgrB | Biaryl bond formation | Cytochrome P450 | Not found | Not found | Installs biaryl crosslink between his-his | |
| MITE0000154 | PeuJ | Hydroxylation | Monooxygenase | Streptomyces seoulensis | Streptomycetaceae | Monooxygenase | |
| MITE0000155 | SrsB | Methylation | Methyltransferase | Streptomyces griseus subsp. griseus NBRC 13350 | Streptomycetaceae | O-methylation of alkylresorcinols to yield alkylresorcinol methyl ethers | |
| MITE0000156 | PhoM | Monooxygenation | Flavin-dependent monooxygenase | Not found | Not found | The monooxygenase PhoM is involved in C5 hydroxlation during biosynethes... | |
| MITE0000157 | PhoL | Reduction | Short-chain dehydrogenases/reductase | Not found | Not found | PhoL is responsible for reduction of monodictyphenone towards the biosyn... | |
| MITE0000158 | PhoJ | Dioxygenation | Dioxygenase | Not found | Not found | PhoJ is a dioxygenase involved in a ring-opening strategy to form monodi... | |
| MITE0000159 | PhoD | Dehydration | Dehydratase | Not found | Not found | PhoD is a dehydratase responsible for the formation of the intermediate ... | |
| MITE0000160 | PhoC | Reduction | Short-chain dehydrogenases/reductase (SDR) | Not found | Not found | PhoD is a reductase responsible for the reduction of a double bond durin... | |
| MITE0000161 | PhoK | Acetylation|Reduction | Reductase | Diaporthe sp. | Sordariomycetes | No description | |
| MITE0000162 | PhoG | Oxidation | Anthrone oxygenase | Not found | Not found | Responsible for the conversion of emodin anthrone to emodin by oxidation... | |
| MITE0000163 | PhoH | Decarboxylation | Decarboxylase | Not found | Not found | Decarboxylase responsible for the conversion of atrochrysone carboxylic ... | |
| MITE0000164 | PhoP | Reduction | Short-chain dehydrogenases/reductase | Not found | Not found | PhoP is a short-chain dehydrogenases/reductase responsible for a reducti... | |
| MITE0000165 | PhoN | Other | Isomerase | Diaporthe sp. | Sordariomycetes | No description | |
| MITE0000166 | ProsF | Methylation | O-methyltransferase | Phaeosphaeria sp. | Dothideomycetes | SAM (S-adenosyl-L-methionine)-depenent O-methylation of roseopurpurin in... | |
| MITE0000167 | ProsD | Hydrolysis | Glyoxalase | Not found | Not found | Ring cleavage in the scope of detoxification. | |
| MITE0000168 | ProsA | Oxidation | Cytochrome P450 | Phaeosphaeria sp. | Dothideomycetes | ProsA works in concert with SDR ProsC to yield the pathway intermediate.... | |
| MITE0000169 | ProsC | Reduction | Short-chain dehydrogenase/reductase | Phaeosphaeria sp. | Dothideomycetes | ProsC works in concert with P450 ProsA to yield the pathway intermediate... | |
| MITE0000170 | ProsK | Cyclization | Cytochrome P450 | Not found | Not found | Depside bond formation by oxidative ether formation. | |
| MITE0000171 | ProsB | Decarboxylation | Decarboxylase | Phaeosphaeria sp. | Dothideomycetes | Decarboxylates the phenolic substrate | |
| MITE0000172 | LauB1 | Biaryl bond formation | Cytochrome P450 | Streptomyces laurentii | Streptomycetaceae | Installs biaryl crosslinks | |
| MITE0000173 | ScaB aka EmbB | Biaryl bond formation | Cytochrome P450 | Not found | Not found | W-W biaryl crosslink formation | |
| MITE0000174 | BytO | Biaryl bond formation | cytochrome P450 | Planomonospora sp | Streptosporangiaceae | Introduces a biaryl bond between Y1 and H3, cytochrome P450 from Planomo... | |
| MITE0000175 | BytO | Biaryl bond formation | cytochrome P450 | Planomonospora sp | Streptosporangiaceae | Biaryl formation between Y1 and H3 of the tripeptide, cytochrome P450, P... | |
| MITE0000176 | Ple1 | Hydroxylation | Cytochrome P450 | Rhodocybe pseudopiperita | Agaricomycetes | Hydroxylation, Ple1 catalyzed hydroxylation on the α position of the ace... | |
| MITE0000177 | Ple2 | Acetylation | Acetyltransferase | Rhodocybe pseudopiperita | Agaricomycetes | Acetylation, O-acetylation of mutilin to produce 14-acetyl-mutilin | |
| MITE0000178 | Ple6 | Hydroxylation | Cytochrome P450 | Rhodocybe pseudopiperita | Agaricomycetes | Hydroxylation | |
| MITE0000179 | Ple5 a.k.a. PLE5_RHOPP | Hydroxylation | Cytochrome P450 | Rhodocybe pseudopiperita | Agaricomycetes | Hydroxylation | |
| MITE0000180 | SLI_0884 | Other | Leucyl/Phenylalanil-tRNA-Protein transferase | Streptomyces lividans 1326 | Streptomycetaceae | amide bond formation between arginine, encoded by the A domain of the NR... | |
| MITE0000181 | FrsC | Reduction | specialized dehydrogenase for phenyllactate biosynthesis | Chromobacterium vaccinii | Chromobacteriaceae | Reduction of phenylpyruvate to L-phenyllactate | |
| MITE0000182 | SxtN | Sulfonation | N-sulfotransferase | Heteroscytonema crispum UCFS15 | Heteroscytonemataceae | N-sulfonation of saxitoxin | |
| MITE0000183 | EryK | Hydroxylation | Cytochrome P450 | Saccharopolyspora erythraea (strain ATCC 11635 / DSM 40517 / JCM 4748 / NBRC 13426 / NCIMB 8594 / NRRL 2338) | Pseudonocardiaceae | C-12 hydroxylation of erythromycin B to form erythromycin A | |
| MITE0000184 | RufO | Other | Cytochrome p450 monooxygenase | Streptomyces atratus | Streptomycetaceae | direct nitration of tyrosine in MRYLH pentapeptide | |
| MITE0000185 | FrsH | Hydroxylation | non-heme diiron monooxygenase | Chromobacterium vaccinii | Chromobacteriaceae | beta-hydroxylation of PCP-bound leucine | |
| MITE0000186 | HrmF | Other | L-DOPA dioxygenase | Streptomyces griseoflavus | Streptomycetaceae | extradiol cleavage of L-DOPA, rearrangement to alkylproline derivative | |
| MITE0000187 | HrmI | Oxidation | heme oxygenase-like dinuclear iron enzyme | Streptomyces griseoflavus | Streptomycetaceae | oxidation of lysine to nitronorleucine | |
| MITE0000188 | BorI | Dehydration|Hydroxylation|Oxidation | Cytochrome P450 monooxygenase | Streptomyces parvulus | Streptomycetaceae | Oxidation of 12-C hydroxyl group of pre-borrelidin to a carbonyl | |
| MITE0000189 | BorJ | Amination | Aminotransferase | Streptomyces parvulus | Streptomycetaceae | Replaces 12-C carbonyl with primary amine on the pre-borrelidin intermediate | |
| MITE0000190 | AurH | Oxidation | Cytochrome P450 Monooxygenase | Streptomyces thioluteus | Streptomycetaceae | Oxidation leads to furan-formation | |
| MITE0000191 | PatG | Decarboxylation | Decarboxylase | Penicillium expansum | Eurotiomycetes | Decarboxylation of 6-methylsalicylic in the patulin biosynthetic pathway | |
| MITE0000192 | CtoA | Halogenation | Halogenase | Sorangium cellulosum | Polyangiaceae | Dichlorination of chlorotonil precursor. | |
| MITE0000193 | AlbA | Dehydrogenation | Albonoursin synthase/cyclic dipeptide oxidase | Streptomyces noursei | Streptomycetaceae | Dehydrogenates cyclo(L-Phe-L-Leu) in the scope of the albonoursin biosyn... | |
| MITE0000194 | PhoO | Biaryl bond formation | Cytochrome P450 | Not found | Not found | PhoO dimerizes penexanthone B to phomoxanthone A | |
| MITE0000195 | HrmJ | Other | alpha-ketoglutarate-dependent dioxygenase | Streptomyces griseoflavus | Streptomycetaceae | cyclopropanation (nitronorleucine - nitrocyclopropylalanine) | |
| MITE0000196 | HynE | Hydroxylation | alpha-ketoglutarate-dependent dioxygenase | Lysobacter sp. K5869 | Lysobacteraceae | beta-hydroxylation of PCP-bound asparagine (anti) | |
| MITE0000197 | HynC | Hydroxylation | non-heme diiron monooxygenase | Lysobacter sp. K5869 | Lysobacteraceae | beta-hydroxylation of PCP-bound tyrosine (syn) | |
| MITE0000198 | PyrH | Halogenation | Flavin-dependent 5-halogenase | Streptomyces rugosporus | Streptomycetaceae | Chlorinates free-floating L-tryptophan exclusively in position 5 | |
| MITE0000199 | NodM | Oxidation | FAD-dependent monooxygenase | Hypoxylon pulicicidum | Sordariomycetes | Single epoxidation | |
| MITE0000200 | NodB | Cyclization | Terpene cyclase | Hypoxylon pulicicidum | Sordariomycetes | Cyclization | |
| MITE0000201 | NodW | Oxidation | Cytochrome P450 Monooxygenase | Hypoxylon pulicicidum | Sordariomycetes | Oxidation terminal methyl | |
| MITE0000202 | BraB | Glycosylation | N-acetylglucosamine transferase | Annulohypoxylon truncatum | Sordariomycetes | Glycosylation | |
| MITE0000203 | braC | Hydroxylation|Oxidation | Cytochrome P450 | Annulohypoxylon truncatum | Sordariomycetes | Hydroxylation at C-12 | |
| MITE0000204 | AoL1 | Oxidation | Short-chain dehydrogenase/reductase (SDR) | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | Eurotiomycetes | AoL1 is an SDR responsible for converting 8-hydroxy aristolochene to 8-o... | |
| MITE0000205 | XhR1 | Carboxylation|Hydroxylation | Cytochrome P450 Monooxygenase | Xylaria hypoxylon | Sordariomycetes | Hydroxylation of isopropenyl side chain of aristolochene. | |
| MITE0000206 | AoL4 | Hydroxylation | Cytochrome P450 | Aspergillus oryzae (strain ATCC 42149 / RIB 40) | Eurotiomycetes | AoL4 is a P450 responsible for converting aristolochene to 8-hydroxy ari... | |
| MITE0000207 | LrcB1 | Hydrolysis | Peptidase Subunit | Paenibacillus sp. M2 | Paenibacillaceae | N-terminal cleavage of leader peptide, resulting in immature intermediat... | |
| MITE0000208 | LrcF | Hydrolysis | Peptidase, clostripain-family | Not found | Not found | C-terminal cleavage of glycin from lassopeptide | |
| MITE0000209 | LrcC | Macrolactam formation | Lassopeptide lactam synthetase | Paenibacillus sp. M2 | Paenibacillaceae | Lassopeptide macrolactam formation after N-terminal cleavage | |
| MITE0000210 | CheE | Monooxygenation | Cytochrome P450 monooxygenase | Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970) | Sordariomycetes | Stereoselective epoxidation of the olefin at C6-7 in the chaetoglobosin ... | |
| MITE0000211 | PyiA | Methylation | O-methyltransferase | Pyricularia grisea | Sordariomycetes | Methylation of L-tyrosine |