Reaction 1

• Reaction SMARTS
• Reaction Information

Copy reaction SMARTS

Description	Installs a biaryl ether bond on the balhiycin precursor. The reaction might be less specific than depicted in the reaction SMARTS. There is no detailed study on the specificity so far. The reaction occurs probably while the precursor peptide backbone is bound to the NRPS as shown for the closely related vancomycin biosynthesis (10.1002/ANIE.200461278).
Tailoring	Cyclization
Database References	No database crosslinks available
Evidence	Knock-out studies
References	doi:10.1002/1521-3773(20011217)40:24<4688::AID-ANIE4688>3.0.CO;2-M doi:10.1016/j.jbiotec.2006.04.009

Example 1

Metadata	Description: Introduces the second crosslink (biaryl ether) between hpg5 and dhpg7 of the balhimycin precursor. Intermediate: True
Substrate 1	Copy SMILES
Product 1	Copy SMILES