MITE0000041

MITE0000042

MITE0000043

Reaction Information

Number of Known Reactions: 7

Reaction 1
reaction SMARTS
Description Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction of UDP-L-4-epi-vancosamine with 6-deoxy-glycosyl-vancomycin-pseudoaglycone.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES
Product 2 product SMILES
Reaction 2
reaction SMARTS
Description Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction of UDP-L-4-epi-vancosamine with 4-deoxy-glycosyl-vancomycin-pseudoaglycone.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES
Product 2 product SMILES
Reaction 3
reaction SMARTS
Description Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction of UDP-L-4-epi-vancosamine with 3-deoxy-glycosyl-vancomycin-pseudoaglycone.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES
Product 2 product SMILES
Reaction 4
reaction SMARTS
Description Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction of UDP-L-4-epi-vancosamine with glycosyl-vancomycin-pseudoaglycone.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES
Product 2 product SMILES
Reaction 5
reaction SMARTS
Description Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction of UDP-L-4-epi-vancosamine with 6-amino-glycosyl-vancomycin-pseudoaglycone.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES
Product 2 product SMILES
Reaction 6
reaction SMARTS
Description Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction of UDP-L-4-epi-vancosamine with 4-amino-glycosyl-vancomycin-pseudoaglycone.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES
Product 2 product SMILES
Reaction 7
reaction SMARTS
Description Transfers vancosamine onto glucose on hpg4 of vancomycin pseudoaglycone.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction of UDP-L-4-epi-vancosamine with 3-amino-glycosyl-vancomycin-pseudoaglycone.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES
Product 2 product SMILES

Enzyme Information

Accession IDMITE0000042
Entry StatusStatus: active
Enzyme NameGtfD
Enzyme DescriptionGlycosyltransferase
Database References
References
CommentThe enzyme accepts the vancomycin and teicoplanin pseudoaglycone as substrate. The substrate tolerance may be even broader than the largest common substructure between vancomycin and teicoplanin.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 reworked reaction SMARTS to allow for a balanced reaction. Reviewer 2 changed text of enzyme description and enzyme reaction description"