MITE0000040

MITE0000041

MITE0000042

Reaction Information

Number of Known Reactions: 2

Reaction 1
reaction SMARTS
Description Introduces the first biaryl-ether crosslink between hpg4 and bht6 in the vancomycin and balhimycin precursors. Reaction occurs while the backbone precursor is bound to the PCP domain of module 6 or 7. The link to the PCP domain is required for the reaction.
Tailoring
  • Cyclization
  • Oxidation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: No description available
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description The reaction probably occurs on the PCP bound precursor.
Tailoring
  • Cyclization
Database References No database crosslinks available
Evidence
  • Knock-out studies
References
Example 1
Metadata
  • Description: The reaction might be less specific than depicted in the reaction SMARTS. There is no detailed study on the specificity so far. Furthermore, the substrate probably needs to be bound to a PCP domain in order to be recognized.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000041
Entry StatusStatus: active
Enzyme NameOxyB
Enzyme DescriptionCytochrome P450
Database References
Cofactors
  • Organic
    • Heme
  • Inorganic
    • Fe
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 fixed reaction SMARTS formatting. Reviewer 1 added information from MITE0000025. Reviewer 2 changed enzyme description."

Version 2 (2025-07-25)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Added cofactor information"

Version 3 (2025-08-13)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Fixed URL formatting"

Version 4 (2025-08-26)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Homogenized enzyme descriptions"