MITE0000039

MITE0000040

MITE0000041

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Chlorinates bht 2 and bht 6 of vancomycin. The bond to the PCP domain of module 2 of the vancomycin NRPS might be important for the reaction. There is no study on the substrate specificity for the second chlorination reaction in vancomycin biosynthesis on bht 6 so far.
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Chemical probe
References
Example 1
Metadata
  • Description: No description available
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000040
Entry StatusStatus: active
Enzyme NameVhaA
Enzyme DescriptionFlavin-dependent halogenase
Database References
Cofactors
  • Organic
    • FAD
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 checked entry for correctness, changed enzyme and reaction description"

Version 2 (2025-01-16)

Contributor(s)
Reviewer(s)
Comment "Fixed typo in enzyme name (Vhal -> VhaA). Reviewer 1 checked for correctness, add reference (doi.org/10.1039/C4OB00474D), change evidence from 'Knock-out studies' to 'Chemical probe', and remove reference (doi:10.1186/1471-2164-15-363) from evidence section."

Version 3 (2025-07-25)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Added cofactor information. Fixed reaction SMARTS indexing."