MITE0000038

MITE0000039

MITE0000040

Reaction Information

Number of Known Reactions: 2

Reaction 1
reaction SMARTS
Description Methylates the N-terminus of the vancomycin backbone. Substrate specificity not known in detail. SMARTS has been designed to be not too unspecific by accident. True substrate specificity might be broader than assumed here.
Tailoring
  • Methylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction from demethyl-vancomycin to vancomycin.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Substrate specificity not known in detail. SMARTS has been designed to be not too unspecific by accident. True substrate specificity might be broader than assumed here.
Tailoring
  • Methylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reaction from demethyl-vancomycin to dimethyl-vancomycin. Vancomycin is usually only monomethylated.
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000039
Entry StatusStatus: active
Enzyme NameVmt
Enzyme DescriptionMethyltransferase
Database References
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 re-drew reaction SMARTS and SMILES to make them RDKit-compatible."