Minimum Information about a Tailoring Enzyme Repository

MITE0000047

MITE0000048

MITE0000049

Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	Cleavage of N-terminal Met from a NH2-Met-Gly-Pro-Xn chain, exposing a N-terminal Gly; bottromycin biosynthesis in Streptomyces sp. BC16019.
Tailoring	Hydrolysis
Database References	No database crosslinks available
Evidence	In vitro assay
References	doi:10.1002/cbic.201600406

Example 1

Metadata	Description: Bottromycin A2-precursor peptide, first 10 AAs; cleaveage of first AA. Intermediate: True
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000048
Entry Status	Status: active
Enzyme Name	BotP
Enzyme Description	Peptidase
Database References	UniProtKB: K4MHW2 NCBI GenPept: AFV25490.1 MIBiG: BGC0000469
References	doi:10.1039/d0np00097c doi:10.1016/j.chembiol.2012.08.013 doi:10.1002/cbic.201600406
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)	0000-0001-6534-6609
Reviewer(s)	0000-0001-6534-6609 0000-0002-9747-3423
Comment	"Initial entry. Reviewer 1 removed parentheses around reaction SMARTS, reaction passes. Reviewer 2 switched text of enzyme description and enzyme reaction description."