MITE0000224
MITE0000225
MITE0000226
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Macrocyclisation of Tyr-phenol-O to Leu-Cβ bond observed in arabipeptin A. A minimum leader sequence KDFESKPGS + follower sequence QG is required for enzymatic activity
Tailoring
  • Cyclization
Database References No database crosslinks available
Evidence
  • Chemical probe
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Minimal recognition sequence ArbA2_62–77 in the wildtype peptide, with the FLWGY core sequence
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Example 2
Metadata
  • Description: Minimal recognition sequence ArbA2_62–77 with a mutated core sequence FLILY
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000225
Entry StatusStatus: active
Enzyme NameArbB2
Enzyme DescriptionBurpitide cyclases/BURP-domain peptide cyclases
Database References
Cofactors
  • Inorganic
    • Cu
References
CommentCopper-dependent cyclase
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-11-15)

Contributor(s)
Reviewer(s)
Comment "new entry. Reviewer 1 adjusted reaction SMARTS to include minimally required leader and follower sequences and updated examples."

Version 2 (2025-12-21)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Fixed captialization of enzyme description."