Minimum Information about a Tailoring Enzyme Repository

MITE0000086

MITE0000087

MITE0000088

Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	RslO4 catalyzes the monooxygenation of an intermediate in the rishirilide biosynthesis pathway
Tailoring	Monooxygenation
Database References	No database crosslinks available
Evidence	Inference from genomic data and chemical structure Knock-out studies Site-directed mutagenesis
References	doi:10.1007/s12033-021-00314-x

Example 1

Metadata	Description: Formation of para-quinone substructure in the rishirilide biosynthesis pathway Intermediate: True
Substrate
Product 1

Enzyme Information

Accession ID	MITE0000087
Entry Status	Status: active
Enzyme Name	RslO4
Enzyme Description	Monooxygenase
Database References	UniProtKB: W8QLE0 NCBI GenPept: AHL46722.1 MIBiG: BGC0001179
References	doi:10.1007/s12033-021-00314-x
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)	Anonymous MITE contributor
Reviewer(s)	0000-0003-4819-2251
Comment	"Initial entry. Reviewer 1 corrected enzyme type as well as tailoring type to monoxygenase, moved reaction descriptions from enzyme type to appropriate fields, added 'inference from genomic data' and 'ko studies' as evidence, as the authors of the papers used KO and complementation studies as well as bioinformatics to infer the role of this protein in the pathway."