MITE0000197

MITE0000198

MITE0000199

Reaction Information

Number of Known Reactions: 2

Reaction 1
reaction SMARTS
Description Chlorinates free-floating L-tryptophan exclusively in position 5
Tailoring
  • Halogenation
Database References
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Chlorinates free-floating L-tryptophan in position 5
  • Intermediate: True
Substrate substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Brominates free-floating L-tryptophan exclusively in position 5
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Brominates free-floating L-tryptophan in position 5
  • Intermediate: True
Substrate substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000198
Entry StatusStatus: active
Enzyme NamePyrH
Enzyme DescriptionFlavin-dependent 5-halogenase
Database References
Cofactors
  • Organic
    • Flavin mononucleotide
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-01-16)

Contributor(s)
Reviewer(s)
Comment "Initial entry, RHEA and EC numbers not available for bromination."

Version 2 (2025-07-25)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Added cofactor information"