Minimum Information about a Tailoring Enzyme Repository

MITE0000220

MITE0000221

MITE0000222

Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	Hydroxylation of polyene macrolide scaffold to yield BE-14106 in Streptomyces sp. DSM 21069
Tailoring	Hydroxylation
Database References	No database crosslinks available
Evidence	Inference from genomic data and chemical structure In vitro assay Knock-out studies
References	doi:10.1016/j.chembiol.2009.09.014

Example 1

Metadata	Description: C-8 hydroxylation of polyene macrolide precursor of BE-14106 Intermediate: False
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000221
Entry Status	Status: active
Enzyme Name	BecO
Enzyme Description	Hydroxylation
Database References	UniParc: UPI00019B338A NCBI GenPept: ACO94467.1
Cofactors	Organic Heme
References	doi:10.1016/j.chembiol.2009.09.014
Comment	P450 monooxygenase hydroxylating polyene macrolide scaffold
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-11-11)

Contributor(s)	0000-0002-8834-593X
Reviewer(s)	0000-0003-4819-2251
Comment	"New entry. Reviewer added cofactor, minor refinements to reaction descriptions."