Minimum Information about a Tailoring Enzyme Repository

MITE0000052

MITE0000053

MITE0000054

Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	macroamidine macrocyclization of Gly1 and Val4 of bottromycin-precursor
Tailoring	Cyclization
Database References	No database crosslinks available
Evidence	Heterologous expression
References	doi:10.1021/jacs.7b09899

Example 1

Metadata	Description: bottromycin A2-precursor peptide after heterocyclization of Cys8 Intermediate: True
Substrate
Product 1

Enzyme Information

Accession ID	MITE0000053
Entry Status	Status: active
Enzyme Name	BotCD
Enzyme Description	Macroamidine linkage-catalyzing YacO protein from Streptomyces sp. BC16019
Database References	UniProtKB: K4MHF8 NCBI GenPept: AFV25483.1 MIBiG: BGC0000469
References	doi:10.1021/jacs.7b09898 doi:10.1039/d0np00097c doi:10.1021/jacs.7b09899
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)	0000-0001-6534-6609
Reviewer(s)	0000-0001-6534-6609
Comment	"Initial entry. Reviewer 1 removed parentheses around reaction SMARTS (falsely indicating an intramolecular reaction), reaction passes."