MITE0000071

MITE0000072

MITE0000073

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description TdaE relies on its substrate as electron donor (rather than NAD(P)H) for O2 activation and covalent flavin-oxygen adduct formation. Then, TdaE incorporates both O2-derived oxygen atoms into the substrate most likely via transient FlN5OO and FlN5O species, thereby breaking the CoA thioester bond and epoxidizing the tropone ring.
Tailoring
  • Dioxygenation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: No description available
  • Intermediate: True
Substrate substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000072
Entry StatusStatus: active
Enzyme NameTdaE
Enzyme DescriptionFlavoprotein dioxygenase
Database References
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 checked crosslinks, factual correctness, and reaction description, UniProt ID yet unreviewed. Reviewer 2 replaced CXSMARTS with normal SMARTS."