MITE0000075

MITE0000076

MITE0000077

Reaction Information

Number of Known Reactions: 2

Reaction 1
reaction SMARTS
Description Flavin-dependent bromination of terminal alkyne
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Bromination of jamaicamide B to jamaicamide A.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Flavin-dependent iodination of terminal alkyne
Tailoring
  • Halogenation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Iodination of jamaicamide B to jamaicamide F.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000076
Entry StatusStatus: active
Enzyme NameJamD
Enzyme DescriptionFlavin-dependent halogenase
Database References
Cofactors
  • Organic
    • FAD
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 simplified reaction SMARTS as JamD is quite promiscuous. Added descriptions for reactions, and added ionidation example from SI of paper"

Version 2 (2025-07-25)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Added cofactor information"