MITE0000032

MITE0000033

MITE0000034

Reaction Information

Number of Known Reactions: 3

Reaction 1
reaction SMARTS
Description Adds N-acetylglucosamine or N-acylglucosamine to Hpg4 of the teicoplanin aglycone. Substrate specificity is probably more general than depicted in the reaction SMARTS, but there is no precise information on substrate specificity. In order to avoid making the reaction too general, the complete backbone is included in the pattern.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: UDP-N-butyryl-glucosamine as substrate.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Adds N-acetylglucosamine or N-acylglucosamine to Hpg4 of the teicoplanin aglycone. Substrate specificity is probably more general than depicted in the reaction SMARTS, but there is no precise information on substrate specificity. In order to avoid making the reaction too general, the complete backbone is included in the pattern.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: UDP-N-acetylglucosamine as substrate.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 3
reaction SMARTS
Description Adds N-acetylglucosamine or N-acylglucosamine to Hpg4 of the teicoplanin aglycone. Substrate specificity is probably more general than depicted in the reaction SMARTS, but there is no precise information on substrate specificity. In order to avoid making the reaction too general, the complete backbone is included in the pattern.
Tailoring
  • Glycosylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: The substrate UDP-glucosamine might not be available as substrate in the cell naturally.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000033
Entry StatusStatus: active
Enzyme NameGtfB
Enzyme DescriptionGlycosyltransferase
Database References
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 fixed reaction SMARTS but had to remove the balanced substrate/product SMILES due to issues with phosphorous chemistry in RDKit. Reviewer 2 switched text of enzyme description and enzyme reaction description"