MITE0000054

MITE0000055

MITE0000056

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Lassopeptide macrolactam formation after N-terminal cleavage: NH2-G-G-X-X-X-X-X-E-X-X-X-X-X-X-X-X-X-X-X-F-X-COOH.
Tailoring
  • Macrolactam formation
Database References No database crosslinks available
Evidence
  • Site-directed mutagenesis
  • Heterologous expression
References
Example 1
Metadata
  • Description: Lasso macrocyclisation of microcin J25 after precursor cleavage, leading to mature product.
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000055
Entry StatusStatus: active
Enzyme NameMcjC
Enzyme DescriptionMacrolactam synthetase
Database References
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 adjusted core peptide recognition pattern to be more explicit."

Version 2 (2025-08-26)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Homogenized enzyme descriptions"

Auxiliary Enzyme #1

Enzyme Name McjB
Description Lassopeptide cysteine protease. Required for macrolactam-synthethase function (folds and cleaves precursor peptide)
Database References