Minimum Information about a Tailoring Enzyme Repository

MITE0000100

MITE0000101

MITE0000102

Reaction Information

Number of Known Reactions: 1

Reaction 1

Tailoring	Heterocyclization
Database References	No database crosslinks available
Evidence	Knock-out studies
References	doi:10.1016/j.apsb.2017.07.005

Example 1

Metadata	Description: No description available Intermediate: True
Substrate
Product 1

Enzyme Information

Accession ID	MITE0000101
Entry Status	Status: active
Enzyme Name	Cxm5
Enzyme Description	Cytochrome P450
Database References	UniProtKB: A0A290YXM6 NCBI GenPept: AVL27080.1 MIBiG: BGC0001485
Cofactors	Organic Heme Inorganic Fe
References	doi:10.1016/j.apsb.2017.07.005
Comment	Atom number nine (in the SMARTS reaction) could be methylated, then this reaction leads to the final product
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)	0000-0003-3002-6458 0000-0001-7044-2419
Reviewer(s)	0000-0001-6534-6609 0000-0003-0443-9902
Comment	"Initial entry. Reviewer partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer 2 fixed reaction SMARTS by specifying explicit hydrogen of aromatic nitrogen and the explicit valence of Carbon nr 14 (zero hydrogen)"

Version 2 (2025-07-25)

Contributor(s)	Anonymous MITE contributor
Reviewer(s)	0000-0001-6534-6609
Comment	"Added cofactor information"