MITE0000014

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description 4-DPMC is the first stable intermediate of the mithramycin biosynthesis. This is converted into PMC by methylation at C-4-O through the MtmMI methyltransferase in Streptomyces argillaceus
Tailoring
  • Methylation
Database References No database crosslinks available
Evidence
  • In vitro assay
  • Knock-out studies
References
Example 1
Metadata
  • Description: No description available
  • Intermediate: True
Substrate substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000014
Entry StatusStatus: active
Enzyme NameMtmMI
Enzyme DescriptionO-methyltransferase
Database References
Cofactors
  • Organic
    • SAM
  • Inorganic
    • FeS
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer 1 added references, checked for factual correctness, added reaction description."

Version 2 (2025-07-25)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Added cofactor information"