MITE0000034

MITE0000035

MITE0000036

Reaction Information

Number of Known Reactions: 4

Reaction 1
reaction SMARTS
Description Deacetylates N-acetylglucosaminyl residue on Hpg4 of the teicoplanin precursor.
Tailoring
  • Hydrolysis
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Generic deacylation of a long chain fatty acid.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Example 2
Metadata
  • Description: Generic deacetylation.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Substrate specificity is probably more general than depicted in the reaction SMARTS, but there is no precise information on substrate specificity. In order to avoid making the reaction too general, the complete backbone is included in the pattern.
Tailoring
  • Hydrolysis
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Describes a deacylation of a C10 carboxylic acid. Probably only slow side reaction during teicoplanin biosynthesis.
  • Intermediate: True
Substrate 1 substrate SMILES
Substrate 2 substrate SMILES
Product 1 product SMILES
Product 2 product SMILES
Reaction 3
reaction SMARTS
Description Substrate specificity is probably more general than depicted in the reaction SMARTS, but there is no precise information on substrate specificity. In order to avoid making the reaction too general, the complete backbone is included in the pattern.
Tailoring
  • Hydrolysis
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Describes the deacetylation.
  • Intermediate: True
Substrate 1 substrate SMILES
Substrate 2 substrate SMILES
Product 1 product SMILES
Product 2 product SMILES
Reaction 4
reaction SMARTS
Description The highest catalytic efficiency of the enzyme is achieved with the glucosaminyl-teicoplanin pseudoaglycone as substrate.
Tailoring
  • Acylation
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: acyl-CoA as co-substrate
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Example 2
Metadata
  • Description: Reaction does not occure naturally during teicoplanin biosynthesis; acyl-CoA as co-substrate.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000035
Entry StatusStatus: active
Enzyme NameTcp24/Orf2*/tAtf
Enzyme DescriptionAcyltransferase
Database References
References
CommentAcyltransferase can use acyl-CoA of different acyl chain length and glucosamine free as UDP-glucosamine or bound to hpg4 of teicoplanin pseudoaglycone as substrates.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer fixed composite SMILES and added a generic version of the reaction. Reviewer 1 added information from retired entry MITE0000036."

Version 2 (2025-08-13)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "Fixed enzyme name to be more computer-readable."