MITE0000113

MITE0000114

MITE0000115

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description NgnM methylates the hydroxyl group at the 2-position of the macrolactone intermediate
Tailoring
  • Methylation
Database References No database crosslinks available
Evidence
  • Knock-out studies
References
Example 1
Metadata
  • Description: No description available
  • Intermediate: True
Substrate substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000114
Entry StatusStatus: active
Enzyme NameNgnM
Enzyme DescriptionMethyltransferase
Database References
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer partially fixed reactions:substrate, validation still not passing. Reviewer partially fixed reactions:products, validation still not passing. Reviewer 2 reworked reaction SMARTS, reaction passes. Reviewer 3 changed enzyme and reaction description."

Auxiliary Enzyme #1

Enzyme Name NgnO3
Description NgnO3 catalyzes the formation of the ether bridge moiety at position C8/C13 of the substrate molecules.
Database References

Auxiliary Enzyme #2

Enzyme Name NgnP2
Description Hydroxylation at c-18
Database References

Auxiliary Enzyme #3

Enzyme Name NgnP1
Description Hydroxylation at c-2
Database References

Auxiliary Enzyme #4

Enzyme Name NgnD
Description [6+4] cycloaddition
Database References

Auxiliary Enzyme #5

Enzyme Name NgnN4
Description NgnN4 is responsible for attaching the pyrrole moiety at hydroxyl group at the 9-position of substrate.
Database References