Minimum Information about a Tailoring Enzyme Repository

MITE0000175

MITE0000176

MITE0000177

Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	Hydroxylation, Ple1 catalyzed hydroxylation on the α position of the acetyl side chain
Tailoring	Hydroxylation
Database References	No database crosslinks available
Evidence	Heterologous expression
References	doi:10.1038/s41467-017-01659-1 doi:10.1002/cbic.201700434

Example 1

Metadata	Description: No description available Intermediate: False
Substrate
Product 1

Enzyme Information

Accession ID	MITE0000176
Entry Status	Status: active
Enzyme Name	Ple1
Enzyme Description	Cytochrome P450
Database References	UniProtKB: A0A6S6QI82 NCBI GenPept: BCI98769.1 MIBiG: BGC0002181
Cofactors	Organic Heme Inorganic Fe
References	doi:10.1038/s41467-017-01659-1 doi:10.1002/cbic.201700434 doi:10.1038/srep25202
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-11-14)

Contributor(s)	0000-0001-6585-0696
Reviewer(s)	0000-0002-9747-3423
Comment	"Initial entry. Reviewer 1 checked for factual correctness of submission incl. references and database ID, added reaction information."

Version 2 (2025-07-25)

Contributor(s)	Anonymous MITE contributor
Reviewer(s)	0000-0001-6534-6609
Comment	"Added cofactor information"