MITE0000227

Reaction Information

Number of Known Reactions: 3

Reaction 1
reaction SMARTS
Description Oxidative cyclization of Y2 and Y6 in the FYYTGY hexapeptide, no leader peptide required. The sequence KRFYYTGYKR did not lead to any products
Tailoring
  • Oxidation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Asperipin-2a intermediate with a single macrocycle
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Oxidative cyclization of Y2 and Y6 in the FYYTGY hexapeptide, no leader peptide required. The sequence KRFYYTGYKR did not lead to any products
Tailoring
  • Oxidation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Two-step macrocyclization leading to Asperipin-2a
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 3
reaction SMARTS
Description Oxidative cyclization of Y2 and Y6 in the FYYTGY hexapeptide, no leader peptide required. The sequence KRFYYTGYKR did not lead to any products
Tailoring
  • Oxidation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Two-step macrocyclization leading to Asperipin-2a-like molecule with N-terminal amine
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000227
Entry StatusStatus: active
Enzyme NameAprY
Enzyme DescriptionOxidase
Database References
Cofactors
  • Organic
    • Ascorbic acid
    • NADP
  • Inorganic
    • Cu
References
CommentDUF3328-containing enzyme. AprY sequence tag (AFLA_041390) found in SI pS10 of referenced paper of Ye et al 2018
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-11-01)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."

Auxiliary Enzyme #1

Enzyme Name AprR
Description Reductase
Database References