MITE0000109

MITE0000110

MITE0000111

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description NgnN4 is responsible for attaching a pyrrole-moiety.
Tailoring
  • Other
Database References No database crosslinks available
Evidence
  • Knock-out studies
References
Example 1
Metadata
  • Description: Installation of pyrrole-moiety at the hydroxyl group at the 9-position of substrate
  • Intermediate: False
Substrate substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000110
Entry StatusStatus: active
Enzyme NameNgnN4
Enzyme DescriptionProline adenyltransferase
Database References
References
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-07-30)

Contributor(s)
Reviewer(s)
Comment "Initial entry. Reviewer partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer partially fixed reactions:substrate, validation still not passing. Reviewer partially fixed reactions:products, validation still not passing. Reviewer 2 fixed pyrrole-nitrogen designation (explicit H), reaction passes."

Auxiliary Enzyme #1

Enzyme Name NgnO3
Description NgnO3 catalyzes the formation of the ether bridge moiety at position C8/C13 of the substrate molecules.
Database References

Auxiliary Enzyme #2

Enzyme Name NgnP2
Description Hydroxylation at c-18
Database References

Auxiliary Enzyme #3

Enzyme Name NgnP1
Description Hydroxylation at c-2
Database References

Auxiliary Enzyme #4

Enzyme Name NgnM
Description NgnM methylates the hydroxyl group at the 2-position of the macrolactone intermediate
Database References