Minimum Information about a Tailoring Enzyme Repository

MITE0000182

MITE0000183

MITE0000184

Reaction Information

Number of Known Reactions: 2

Reaction 1

Description	C-12 hydroxylation of erythromycin B to form erythromycin A
Tailoring	Hydroxylation
Database References	No database crosslinks available
Evidence	In vitro assay Knock-out studies
References	doi:10.1111/j.1472-765X.2010.02973.x

Example 1

Metadata	Description: No description available Intermediate: False
Substrate
Product 1

Reaction 2

Description	C-12 hydroxylation of erythromycin D to form erythromycin C
Tailoring	Hydroxylation
Database References	RHEA: 32631 BRENDA: 1.14.13.154 Expasy ENZYME: 1.14.13.154
Evidence	In vitro assay Knock-out studies
References	doi:10.1111/j.1472-765X.2010.02973.x

Example 1

Metadata	Description: No description available Intermediate: True
Substrate
Product 1

Enzyme Information

Accession ID	MITE0000183
Entry Status	Status: active
Enzyme Name	EryK
Enzyme Description	Cytochrome P450
Database References	UniProtKB: P48635 NCBI GenPept: CAM00054.1 MIBiG: BGC0000055
Cofactors	Organic Heme Inorganic Fe
References	doi:10.1021/bi00006a006 doi:10.1111/j.1472-765X.2010.02973.x
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2024-11-28)

Contributor(s)	0000-0002-4058-6718
Reviewer(s)	0000-0001-6534-6609
Comment	"New entry. Reviewer 1 added reaction databaseID crosslinks."

Version 2 (2025-07-25)

Contributor(s)	Anonymous MITE contributor
Reviewer(s)	0000-0001-6534-6609
Comment	"Added cofactor information"