MITE0000259
MITE0000260
MITE0000261
Modify entry

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Cyclodehydration of cystein-thiol with preceding peptide bond
Tailoring
  • Dehydration
  • Heterocyclization
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • Knock-out studies
References
Example 1
Metadata
  • Description: Cyclodehydration reactions in NosM precursor peptide in nosiheptide biosynthesis
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000260
Entry StatusStatus: active
Enzyme NameNosG
Enzyme DescriptionE1-YcaO didomain protein
Database References
References
CommentNosG forms a cyclodehydratase complex with NosH, the latter acting as RiPP recognition element. It further interacts with NosF as NosFGH complex in nosiheptide formation.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-12-30)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."

Auxiliary Enzyme #1

Enzyme Name NosH
Description Ocin-ThiF-like protein
Database References

Auxiliary Enzyme #2

Enzyme Name NosF
Description Dehydrogenase
Database References