MITE0000257
MITE0000258
MITE0000259
Modify entry

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Attaches 3-methyl-2-indolic acid (MIA) via through S-MIAylation to Cys8 in the nosiheptin biosynthetic pathway. Current knowledge indicates that the full leader peptide is required for substrate recognition.
Tailoring
  • Other
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • Knock-out studies
References
Example 1
Metadata
  • Description: Attachment of MIA to Cys of the modified NosM precursor peptide.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000258
Entry StatusStatus: active
Enzyme NameNosK
Enzyme DescriptionAlpha/beta-hydrolase fold protein
Database References
References
CommentNosK works in tandem with NosI and NosJ to perform the post-translational modification.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-12-30)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."

Auxiliary Enzyme #1

Enzyme Name NosI
Description Adenylation protein
Database References

Auxiliary Enzyme #2

Enzyme Name NosJ
Description Thiolation protein
Database References