Reaction 1

• Reaction SMARTS
• Reaction Information

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Description	Cleavage of nisin precursor peptide (prepeptide) by recognizing the GASPR cleavage site. Presence of lantionine-rings is essential for cleavage in vivo, but not strictly necessary in vitro.
Tailoring	Hydrolysis
Database References	No database crosslinks available
Evidence	Heterologous expression In vitro assay Site-directed mutagenesis
References	doi:10.1021/acs.biochem.7b00524

Example 1

Metadata	Description: Cleavage of nisin A precursor peptide, resulting in mature and bioactive nisin A. Intermediate: False
Substrate 1	Copy SMILES
Product 1	Copy SMILES