MITE0000233
MITE0000234
MITE0000235
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description (Methyl-)lanthionine formation between dehydrated Ser/Thr and Cys on nisin precursor peptide modified by NisB.
Tailoring
  • Cyclization
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
  • Site-directed mutagenesis
References
Example 1
Metadata
  • Description: Macrocyclisation of dehydrated nisin A precursor peptid during maturation.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000234
Entry StatusStatus: active
Enzyme NameNisC
Enzyme DescriptionLanthionine synthetase
Database References
Cofactors
  • Inorganic
    • Zn
References
Comment(Methyl-)Lanthionine macrocycle formation relatively flexible. No ATP required for reaction.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-12-29)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."