MITE0000232
MITE0000233
MITE0000234
Modify entry

Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Dehydration of ser/thr in nisin A precursor peptide. Leader peptide with FNLD sequence ("box") essential for recognition.
Tailoring
  • Dehydration
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • Knock-out studies
  • Surface plasmon resonance
References
Example 1
Metadata
  • Description: Dehydration of the NisA precursor peptide. Ser29 is not dehydrated.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000233
Entry StatusStatus: active
Enzyme NameNisB
Enzyme DescriptionDehydratase
Database References
Cofactors
  • Organic
    • Adenosine triphosphate
  • Inorganic
    • Mg
References
CommentDehydration relatively flexible, with hydrophobic flanking AAs preferred. Ser29 (non-dehydrated in vivo) could be dehydrated in vitro. Glutamate is also required as cofactor.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-12-28)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."