Minimum Information about a Tailoring Enzyme Repository

MITE0000326

MITE0000327

MITE0000328

Modify entry

Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	MgsI is responsible for enoyl reduction of the C-16/C-17 olefin in iso-migrastatin biosynthesis
Tailoring	Reduction
Database References	No database crosslinks available
Evidence	Knock-out studies
References	doi:10.1021/ja4002635

Example 1

Metadata	Description: enoyl reduction of the C-16/C-17 olefin in iso-migrastatin biosynthesis Intermediate: False
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000327
Entry Status	Status: active
Enzyme Name	MgsI
Enzyme Description	Oxidoreductase
Database References	UniProtKB: D0U2E7 NCBI GenPept: ACY01394.1 MIBiG: BGC0000177
References	doi:10.1021/ja4002635
Comment	enoyl reduction of the C-16/C-17 olefin in iso-migrastatin biosynthesis
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-04-14)

Contributor(s)	0000-0002-4540-6501
Reviewer(s)	0000-0002-9747-3423 0000-0001-6534-6609
Comment	"New entry. Reviewer 2 fixed reaction SMARTS, substrate, and product (methyl- instead of hydroxy-group."