Minimum Information about a Tailoring Enzyme Repository

MITE0000325

MITE0000326

MITE0000327

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Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	C-8 hydroxylation of iso-migrastatin core structure
Tailoring	Hydroxylation
Database References	No database crosslinks available
Evidence	Knock-out studies
References	doi:10.1021/ja4002635

Example 1

Metadata	Description: C-8 hydroxylation of iso-migrastatin core structure Intermediate: True
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000326
Entry Status	Status: active
Enzyme Name	MgsK
Enzyme Description	oxidoreductase
Database References	UniProtKB: D0U2E9 NCBI GenPept: ACY01396.1 MIBiG: BGC0000177
Cofactors	Organic NADP
References	doi:10.1021/ja4002635
Comment	C-8 hydroxylation of iso-migrastatin core structure
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-04-14)

Contributor(s)	0000-0002-4540-6501
Reviewer(s)	0000-0002-9747-3423 0000-0001-6534-6609
Comment	"New entry. Reviewer 2 fixed reaction SMARTS to correctly represent the core structure and corrected protein cross-refs."