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Reaction Information
Number of Known Reactions: 2
Reaction 1
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| Description | Stereoselective dehydration |
| Tailoring |
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| Database References | No database crosslinks available |
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Example 1
| Metadata |
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| Substrate 1 |
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| Product 1 |
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Reaction 2
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| Description | Hetero Diels-Alder reaction |
| Tailoring |
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| Database References | No database crosslinks available |
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Example 1
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| Substrate 1 |
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| Product 1 |
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Enzyme Information
| Accession ID | MITE0000316 |
| Entry Status | Status: active |
| Enzyme Name | LepI |
| Enzyme Description | SAM-dependent pericyclase |
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| Comment | S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that can catalyse stereoselective dehydration followed by three pericyclic transformations: intramolecular Diels–Alder and hetero-Diels–Alder reactions via a single ambimodal transition state, and a retro-Claisen rearrangement |
| Enzyme Visualization (AlphaFold-predicted) |
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Version 1 (2026-03-25)
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