MITE0000278
MITE0000279
MITE0000280
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Oxidative C–Se bond formation between hercynine and SeGlcNAc, yielding a selenoxide intermediate (GlcNAc-SEN=O) that spontaneously undergoes selenoxide elimination to produce selenoneine and 2-acetamidoglucal (2AG).
Tailoring
  • Other
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
  • Site-directed mutagenesis
References
Example 1
Metadata
  • Description: hercynine + SeGlcNAc → Product: selenoneine + 2-acetamidoglucal (2AG)
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000279
Entry StatusStatus: active
Enzyme NameSenA
Enzyme DescriptionSelenoneine synthase
Database References
Cofactors
  • Inorganic
    • Fe
References
CommentFe(II)- and O₂-dependent nonhaem iron enzyme; homologue of ergothioneine sulfoxide synthase EgtB. Catalyses oxidative C–Se bond formation between hercynine and SeGlcNAc via a selenoxide intermediate that spontaneously eliminates to yield selenoneine and 2-acetamidoglucal.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-04-02)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."