Reaction 1

• Reaction SMARTS
• Reaction Information

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Description	Introduction of 23-membered main macrocyclic ring system in nosiheptide via a formal [4+2] cycloaddition reaction, with removal of leader peptide.
Tailoring	Cyclization
Database References	No database crosslinks available
Evidence	Heterologous expression In vitro assay Knock-out studies
References	doi:10.1021/jacs.5c03922

Example 1

Metadata	Description: Introduction of main ring system by pyridine introduction in the nascent nosiheptide precursor peptide. Intermediate: True
Substrate 1	Copy SMILES
Product 1	Copy SMILES