MITE0000252
MITE0000253
MITE0000254
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description NosA cleaves C-alpha-N bond of terminal enamine in nosiheptide maturation. Presence of hydroxylated pyridin is essential for substrate recognition.
Tailoring
  • Other
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
  • Knock-out studies
References
Example 1
Metadata
  • Description: Dealkylation of terminal enamine in nosiheptide biosynthesis.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000253
Entry StatusStatus: active
Enzyme NameNosA
Enzyme DescriptionTerminal amide synthase
Database References
References
CommentPart of the NosABC hydroxylation cascade, leading to mature nosiheptide.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2025-12-31)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry."