MITE0000247
MITE0000248
MITE0000249
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Transacylation of side chain of isopenicillin N in the biosynthetic pathway of penicillin G.
Tailoring
  • Acylation
Database References
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: Transacylation of isopenicillin N to penicillin G (benzylpenicillin) by replacement of alpha-aminoadipyl side chain with phenylacetly moiety.
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000248
Entry StatusStatus: active
Enzyme NamePenDE
Enzyme DescriptionAcyl-CoA:isopenicillin N N-acyltransferase
Database References
Cofactors
  • Organic
    • Coenzyme A
References
CommentCatalyzes the exchange of the alpha-aminoadipyl side chain of IPN with a phenylacetyl moiety, to yield penicillin G.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-01-01)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry. Added original ref, minor corrections to reaction descriptions. Replaced Uniref database ref with Uniprot ID."