MITE0000242
MITE0000243
MITE0000244
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description TamL oxidizes the C-10 hydroxy to a keton in the tirandamycin biosynthetic pathway. High substrate specificity.
Tailoring
  • Oxidation
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
  • Knock-out studies
References
Example 1
Metadata
  • Description: Oxidizes tirandamycin E to tirandamycin D.
  • Intermediate: True
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000243
Entry StatusStatus: active
Enzyme NameTamL
Enzyme DescriptionFAD-dependent oxidase
Database References
Cofactors
  • Organic
    • FAD
References
CommentWorks in tandem with TamI in tirandamycin biosynthesis in a oxygenation-oxidation-oxygenation cascade.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-01-01)

Contributor(s)
  • Anonymous MITE contributor
Reviewer(s)
Comment "New entry. Reviewer fixed typos."

Auxiliary Enzyme #1

Enzyme Name TamI
Description Cytochrome P450
Database References