MITE0000239
MITE0000240
MITE0000241
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Reaction Information

Number of Known Reactions: 3

Reaction 1
reaction SMARTS
Description Reductive cyclization to form a 6-membered ring.
Tailoring
  • Cyclization
  • Reduction
Database References No database crosslinks available
Evidence
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Reductive cyclization of 3-deOH alteramide C, leading to 3-deOH HSAF (Heat Stable Antifungal factor).
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Reductive cyclization to form a 5-membered ring.
Tailoring
  • Cyclization
  • Reduction
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reductive cyclization of preikarugamycin intermediate, leading to ikarugamycin.
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 3
reaction SMARTS
Description Reductive cyclization to form a 5-membered ring.
Tailoring
  • Cyclization
  • Reduction
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reductive cyclization of preikarugamycin intermediate, leading to isoikarugamycin.
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000240
Entry StatusStatus: active
Enzyme NameOX4
Enzyme DescriptionAlcohol dehydrogenase/reductase
Database References
Cofactors
  • Organic
    • NAD
    • NADP
References
CommentReductive cyclization of five- (ikarugamycin) and six-membered (alteramide) rings in polycyclic tetramate macrolactams.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-01-02)

Contributor(s)
Reviewer(s)
Comment "New entry. Reviewer added descriptions and isoikarugamycin reaction."