MITE0000238
MITE0000239
MITE0000240
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Reductive cyclization to form a 5-membered ring in ikarugamycin pathway.
Tailoring
  • Cyclization
  • Reduction
Database References No database crosslinks available
Evidence
  • In vitro assay
References
Example 1
Metadata
  • Description: Reductive cyclization of preikarugamycin intermediate, leading to ikarugamycin.
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000239
Entry StatusStatus: active
Enzyme NameIkaC
Enzyme DescriptionAlcohol dehydrogenase/reductase
Database References
Cofactors
  • Organic
    • NAD
    • NADP
References
CommentReductive cyclization of five-membered ring (ikarugamycin) in polycyclic tetramate macrolactams.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-01-08)

Contributor(s)
Reviewer(s)
Comment "New entry. Reviewer modified descriptions."