Minimum Information about a Tailoring Enzyme Repository

MITE0000321

MITE0000322

MITE0000323

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Reaction Information

Number of Known Reactions: 1

Reaction 1

Description	Cytochrome P450 monooxygenase responsible for C10-hydroxylation in last step of nystatin A1 biosynthesis
Tailoring	Hydroxylation Monooxygenation
Database References	No database crosslinks available
Evidence	In vitro assay
References	doi:10.1007/s00253-004-1802-4 doi:10.1128/AEM.72.4.2514-2519.2006

Example 1

Metadata	Description: No description available Intermediate: False
Substrate 1
Product 1

Enzyme Information

Accession ID	MITE0000322
Entry Status	Status: active
Enzyme Name	NysL
Enzyme Description	monooxygenase / hydroxylase
Database References	UniProtKB: Q9L4X0 NCBI GenPept: AAF71769.1 MIBiG: BGC0000115
Cofactors	Organic Heme Inorganic Fe
References	doi:10.1007/s00253-004-1802-4 doi:10.1128/AEM.72.4.2514-2519.2006
Comment	Cytochrome P450 monooxygenase responsible for C10-hydroxylation in last step of nystatin A1 biosynthesis
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-04-14)

Contributor(s)	0000-0001-5730-3326
Reviewer(s)	0000-0001-5863-7248 0000-0001-6534-6609
Comment	"New entry. Reviewer 2 fixed missing hemicetal in substrate"