MITE0000262
MITE0000263
MITE0000264
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Reaction Information

Number of Known Reactions: 1

Reaction 1
reaction SMARTS
Description Forms two C–C bonds in the precursor peptide WgkA: Trp18-C5 to Lys20-Cα and Trp18-C6 to Lys20-Cδ. The stereochemistry at Lys Cα and Cδ in the product is not known.
Tailoring
  • Cyclization
Database References No database crosslinks available
Evidence
  • Heterologous expression
  • In vitro assay
References
Example 1
Metadata
  • Description: No description available
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE0000263
Entry StatusStatus: active
Enzyme NameWgkB
Enzyme DescriptionRadical SAM enzyme
Database References
Cofactors
  • Organic
    • SAM
  • Inorganic
    • FeS
References
CommentCyclizes the precursor peptide WgkA, forming two C–C bonds between Trp18 and Lys20. This is the first tailoring step in tryglysin A biosynthesis.
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-03-11)

Contributor(s)
Reviewer(s)
Comment "New entry."

Auxiliary Enzyme #1

Enzyme Name WgkC
Description RiPP Recognition Element
Database References