Reviewer mode

Submission ID: 170c32aa-ec85-11f0-8cfa-42e140a9826e

Reaction Information

Number of Known Reactions: 2

Reaction 1
reaction SMARTS
Description Reductive cyclization to form a 5-membered ring in ikarugamycin (less selective than IkaC and CftD)
Tailoring
  • Cyclization
  • Reduction
Database References No database crosslinks available
Evidence
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Reductive cyclization to form a 5-membered ring in ikarugamycin
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES
Reaction 2
reaction SMARTS
Description Reductive cyclization to form a 5-membered ring in isoikarugamycin (less selective than IkaC and CftD)
Tailoring
  • Cyclization
  • Reduction
Database References No database crosslinks available
Evidence
  • Inference from genomic data and chemical structure
  • In vitro assay
References
Example 1
Metadata
  • Description: Reductive cyclization to form a 5-membered ring in isoikarugamycin
  • Intermediate: False
Substrate 1 substrate SMILES
Product 1 product SMILES

Enzyme Information

Accession IDMITE9999999
Entry StatusStatus: pending
Enzyme NamePtmC
Enzyme Descriptiondehydrogenase/reductase
Database References
Cofactors
  • Organic
    • NAD
    • NADP
References
CommentNAD(P)H-dependent medium-chain dehydrogenase/reductase from Streptomyces pactum SCSIO 02999
Enzyme Visualization (AlphaFold-predicted)

Version 1 (2026-01-08)

Contributor(s)
Reviewer(s)
  • Entry not reviewed (but all automated validation checks passed)
Comment "new entry."