{
    "accession": "MITE0000026",
    "status": "retired",
    "retirementReasons": [
        "Entry addresses same enzyme as MITE0000038 (OxyA), but references the wrong MIBiG entry. All information has been transferred to MITE0000038."
    ],
    "changelog": [
        {
            "version": "1",
            "date": "2024-07-30",
            "contributors": [
                "0009-0008-7609-4484"
            ],
            "reviewers": [
                "0000-0001-6534-6609",
                "0000-0003-0443-9902"
            ],
            "comment": "Initial entry. Reviewer 1 partially fixed reactionSMARTS:reactionSMARTS, validation still not passing. Reviewer 1 partially fixed reactions:substrate, validation still not passing. Reviewer 1 partially fixed reactions:products, validation still not passing. Reviewer 2 reworked reaction SMARTS from scratch, reaction passing. Reviewer 2 retired entry (duplicate of MITE0000038)."
        },
        {
            "version": "2",
            "date": "2025-07-25",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Added cofactor information"
        },
        {
            "version": "3",
            "date": "2025-08-26",
            "contributors": [
                "AAAAAAAAAAAAAAAAAAAAAAAA"
            ],
            "reviewers": [
                "0000-0001-6534-6609"
            ],
            "comment": "Homogenized enzyme descriptions"
        }
    ],
    "enzyme": {
        "name": "OxyA",
        "description": "Cytochrome P450",
        "references": [
            "doi:10.1016/j.jbiotec.2006.04.009",
            "doi:10.1128/AAC.43.7.1565",
            "doi:10.1002/1521-3773(20011217)40:24%3C4688::aid-anie4688%3E3.0.co;2-m"
        ],
        "databaseIds": {
            "uniprot": "F8STX6",
            "genpept": "AEI58868.1",
            "mibig": "BGC0000311"
        },
        "cofactors": {
            "inorganic": [
                "Fe"
            ],
            "organic": [
                "Heme"
            ]
        }
    },
    "reactions": [
        {
            "tailoring": [
                "Cyclization"
            ],
            "description": "Introduces the second crosslink (biaryl ether).",
            "reactionSMARTS": "[#6:1]-[#6:2](-[#6:67])-[#6:3]-[#6:4](-[#7:66])-[#6:5](=[#8:65])-[#7:6]-[#6:7](-[#6:55](-[#8:64])-[#6:56]1:[#6:63]:[#6:62]:[#6:60](-[#8:61]):[#6:58](-[Cl:59]):[#6:57]:1)-[#6:8](=[#8:54])-[#7:9]-[#6:10](-[#6:50]-[#6:51](-[#7:53])=[#8:52])-[#6:11](=[#8:49])-[#7:12]-[#6:13]1-[#6:42](=[#8:43])-[#7:41]-[#6:33](-[#6:34]2:[#6:40]:[#6:39]:[#6:37](-[#8:38]):[#6:36]:[#6:35]:2)-[#6:31](=[#8:32])-[#7:30]-[#6:26](-[#6:27](-[#8:29])=[#8:28])-[#6:24](-[#8:25])-[#6:21]2:[#6:22]:[#6:23]:[#6:18](:[#6:19](-[Cl:44]):[#6:20]:2)-[#8:17]-[#6:16]2:[#6:45](:[#6:47]:[#6:48]:[#6:14]-1:[#6:15]:2)-[#8:46]>>[#6:1]-[#6:2](-[#6:67])-[#6:3]-[#6:4](-[#7:66])-[#6:5](=[#8:65])-[#7:6]-[#6:7]1-[#6:55](-[#8:64])-[#6:56]2:[#6:63]:[#6:62]:[#6:60](-[#8:61]-[#6:47]3:[#6:48]:[#6:14]4:[#6:15]:[#6:16](:[#6:45]:3-[#8:46])-[#8:17]-[#6:18]3:[#6:23]:[#6:22]:[#6:21](-[#6:24](-[#6:26](-[#7:30]-[#6:31](-[#6:33](-[#7:41]-[#6:42](=[#8:43])-[#6:13]-4-[#7:12]-[#6:11](=[#8:49])-[#6:10](-[#6:50]-[#6:51](-[#7:53])=[#8:52])-[#7:9]-[#6:8]-1=[#8:54])-[#6:34]1:[#6:40]:[#6:39]:[#6:37](-[#8:38]):[#6:36]:[#6:35]:1)=[#8:32])-[#6:27](-[#8:29])=[#8:28])-[#8:25]):[#6:20]:[#6:19]:3-[Cl:44]):[#6:58](-[Cl:59]):[#6:57]:2",
            "reactions": [
                {
                    "substrate": "CC(C)CC(N)C(=O)NC(C(=O)NC(CC(N)=O)C(=O)NC1C(=O)NC(c2ccc(O)cc2)C(=O)NC(C(=O)O)C(O)c2ccc(c(Cl)c2)Oc2cc1ccc2O)C(O)c1ccc(O)c(Cl)c1",
                    "products": [
                        "CC(C)CC(N)C(=O)NC1C(=O)NC(CC(N)=O)C(=O)NC2C(=O)NC(c3ccc(O)cc3)C(=O)NC(C(=O)O)C(O)c3ccc(c(Cl)c3)Oc3cc2cc(c3O)Oc2ccc(cc2Cl)C1O"
                    ],
                    "isIntermediate": true
                }
            ],
            "evidence": {
                "evidenceCode": [
                    "Knock-out studies"
                ],
                "references": [
                    "doi:10.1002/1521-3773(20011217)40:24%3C4688::aid-anie4688%3E3.0.co;2-m",
                    "doi:10.1016/j.jbiotec.2006.04.009"
                ]
            }
        }
    ]
}